What Is a Polynucleotide Facial?
Polynucleotide Facial Perth (Belmont)
DNA skin renewal using salmon-derived polynucleotide fragments — designed to support hydration, texture and natural radiance from within.
Polynucleotide facials — also known as DNA skin renewal — are one of the most talked-about treatments in skin rejuvenation right now — and for good reason. Unlike treatments that add volume or relax muscles, polynucleotides work at a cellular level to support your skin’s own repair and renewal processes. The result? Skin that looks healthier, more hydrated, and naturally refreshed.
Administered by AHPRA-registered health professionals. From $699 per session, or $1,800 for a course of 3 (saving $297).
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What Is a Polynucleotide Facial (DNA Skin Renewal)?
A polynucleotide facial is an injectable skin treatment that uses purified DNA fragments derived from salmon. These fragments — called polynucleotides — are highly biocompatible with human skin and are studied for their ability to support the skin’s natural regenerative processes.
When injected beneath the skin’s surface by a qualified health professional, polynucleotides may help stimulate fibroblast activity (the cells responsible for producing collagen and elastin), support hydration from within, and improve overall skin quality over time.
Think of it as helping your skin work better from the inside — rather than adding something to the surface or filling in lines. It’s sometimes described as a “bio-regenerative” treatment because it works with your body’s own biology.
This is different from dermal fillers (which add volume), bio-remodellers (which spread hyaluronic acid), and anti-wrinkle injections (which relax muscles). Polynucleotides occupy their own category — focused purely on skin quality, texture, and resilience.
What Concerns Can This Treatment Address?
Polynucleotide facials are commonly chosen by clients who want to improve overall skin quality rather than target a single wrinkle or line:
- Dull, tired-looking skin that lacks radiance
- Fine lines and early signs of skin ageing
- Uneven skin texture or roughness
- Dehydrated skin that doesn’t respond well to topical products alone
- Under-eye area concerns (fine lines, crepiness)
- Skin affected by sun exposure or environmental stress
- Post-treatment support (pairs well with needling, peels, or other procedures)
This is not a volumising treatment and won’t lift or fill. If your primary concern is volume loss, sagging, or deep lines, we may recommend an alternative during your consultation.
Polynucleotides vs Other Skin Treatments
| Polynucleotides | Bio-Remodelling | Skin Needling | HydraFacial | |
|---|---|---|---|---|
| Type | Injectable | Injectable | Device-based | Device-based |
| Primary benefit | Cellular repair & regeneration | Deep hydration & HA boost | Collagen stimulation | Cleanse & hydrate |
| Results timeline | 4–12 weeks | 2–4 weeks | 4–6 weeks | Immediate |
| Sessions | 2–3 initial | 2 initial | 3–6 course | Ongoing monthly |
| Downtime | 1–2 days mild | 1–2 days mild | 1–3 days | None |
| Price at Equinox | From $699 | Consultation required | From $169 | From $149 |
| Best for | Skin quality & texture | Hydration & fine lines | Texture & scarring | Glow & maintenance |
Is This Treatment Right for Me?
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May be a great fit if: – You want to improve overall skin quality, hydration, and texture – You’re looking for a treatment that supports your skin’s natural processes – You prefer a gradual, natural-looking improvement over time – Your skin looks tired, dull, or lacks its former radiance – You want to complement other treatments (needling, peels, HIFU)
May not be suitable if: – You have a known allergy to fish or seafood – You are pregnant or breastfeeding – You have active skin infections or inflammation in the treatment area – You’re looking for immediate, dramatic change (volume, lift)
We’ll confirm suitability during your consultation.
Polynucleotide Facial
Single SessionPolynucleotide Facial
3 Session CourseAdd-On: Polynucleotides with Skin Needling
Your Treatment Journey
- Consultation: Your skin is assessed, concerns discussed, suitability confirmed. Your practitioner creates a tailored plan.
- Preparation: Skin is cleansed. Topical numbing may be applied for comfort.
- Treatment: Polynucleotides are delivered beneath the skin via precise microinjections. Most clients describe the sensation as mild prickling — manageable and brief.
- Immediately after: You may notice mild redness, small bumps, or bruising at injection sites. These typically settle within 24–48 hours.
- Over the following weeks: Skin quality improves gradually as your body’s regenerative processes respond to the treatment. Most clients notice clearer, more hydrated skin from week 2–4, with continued improvement over 4–12 weeks.
- Course progression: Each session builds on the last. The full course of 2–3 sessions delivers the best overall improvement in skin quality.
What’s the difference between polynucleotides and dermal fillers?
Polynucleotides support skin regeneration and quality from within — they don’t add volume. Dermal fillers physically add volume to specific areas.
Is there downtime?
Minimal. Mild redness, small bumps, or bruising for 1–2 days. Most clients return to normal activities the same day.
What is a polynucleotide facial?
An injectable skin rejuvenation treatment using purified DNA fragments derived from salmon. Polynucleotides support the skin’s natural repair and renewal processes, improving hydration, texture, and overall skin quality.
How much does a polynucleotide facial cost in Perth?
At Equinox in Belmont, a single session is $699. A course of 3 sessions is $1,800 (saving $297 compared to individual sessions).
How many sessions do I need?
A course of 2–3 sessions spaced approximately 3 weeks apart is recommended. Top-up sessions every 6–12 months help maintain results.
How long do polynucleotide results last?
Results typically last 6–12 months depending on skin type, lifestyle, and maintenance. Periodic top-up sessions help sustain improvements.
Is a polynucleotide facial the same as a Korean Glass Facial?
No. A polynucleotide facial focuses on skin regeneration using polynucleotides alone. The Korean Glass Facial ($999) is a multi-step protocol combining several injectable ingredients for an immediate “glass skin” glow. → Korean Glass Facial Perth
Equinox Beauty & Cosmetic Clinic
Belmont Forum Shopping Centre, 227 Belmont Ave, Cloverdale WA 6105
Mon–Wed & Fri: 9am–5pm | Thu: 9am–8pm | Sat: 9am–4pm | Sun: Closed
Equinox Beauty & Cosmetic Clinic
227 Belmont Ave
Cloverdale WA 6105
Serving Perth, Belmont, Cloverdale, Victoria Park, South Perth, Como, Applecross, Mount Pleasant, Ascot, Rivervale, Carlisle, Burswood, Kewdale, and surrounding suburbs.
Individual results vary. This treatment is not suitable for everyone. A consultation is recommended.
I have a fish allergy — can I have this treatment?
No. Polynucleotides are derived from salmon DNA. If you have a known allergy to fish or seafood, this treatment is not suitable.
Can I combine polynucleotides with skin needling?
Yes — this is a popular combination. Polynucleotides can be added to a skin needling session for $140, allowing the active ingredients to penetrate through the micro-channels for enhanced results.
How is this different from bio-remodelling?
Bio-remodelling uses hyaluronic acid to deeply hydrate and improve skin laxity. Polynucleotides focus on cellular regeneration and repair. They address different aspects of skin quality and can complement each other.
Will I look “done”?
No. Polynucleotide results are gradual and natural-looking. There’s no volume change or frozen appearance — just healthier, more hydrated skin.